{"id":2157,"date":"2024-08-22T19:43:36","date_gmt":"2024-08-22T19:43:36","guid":{"rendered":"https:\/\/capahc.com\/?p=2157"},"modified":"2025-01-14T17:25:32","modified_gmt":"2025-01-14T17:25:32","slug":"laustralie-en-voie-deliminer-le-vhc-chez-les-harsah-dici-2030","status":"publish","type":"post","link":"https:\/\/capahc.com\/en\/laustralie-en-voie-deliminer-le-vhc-chez-les-harsah-dici-2030\/","title":{"rendered":"Australia on track to eliminate HCV in men who have sex with men (MSM) by 2030"},"content":{"rendered":"

Australia on track to eliminate HCV in men who have sex with men (MSM) by 2030<\/h1>\n\n\n\n

L\u2019h\u00e9patite C affecte de mani\u00e8re disproportionn\u00e9e les hommes ayant des relations sexuelles avec d\u2019autres hommes (HARSAH) vivant avec le VIH. Une infime partie de HARSAH s\u00e9ron\u00e9gatifs \u2013 plus particuli\u00e8rement ceux prenant la PrEP \u2013 peuvent aussi \u00eatre affect\u00e9s. Cependant, l\u2019introduction des antiviraux \u00e0 action directe (AAD) a simplifi\u00e9 et am\u00e9lior\u00e9 les traitements de l\u2019h\u00e9patite C de mani\u00e8re significative \u2013 les combinaisons d\u2019AAD permettent d\u2019obtenir des taux de r\u00e9ponse virologique soutenue (RVS) dans plus de 90 % des cas. De plus, le statut VIH du patient n\u2019a pas d\u2019effet sur l\u2019efficacit\u00e9 des AAD.<\/strong><\/p>\n\n\n\n

Dans une \u00e9tude<\/a> men\u00e9e par le Dr Brendan Harney, B. L., & al. (Clinical Infectious Diseases<\/em>, 2021) de la Monash University \u00e0 Melbourne (Australie), les r\u00e9sultats ont d\u00e9montr\u00e9 que l\u2019acc\u00e8s aux AAD pour gu\u00e9rir l\u2019h\u00e9patite C<\/a> a fortement fait baisser les taux d\u2019incidence du VHC<\/strong> chez les groupes particuliers les plus affect\u00e9s en Australie, comme notamment les HARSAH vivant avec le VIH. Une tendance similaire<\/strong> dans les infections de l\u2019h\u00e9patite C a \u00e9t\u00e9 observ\u00e9e pour les hommes s\u00e9ron\u00e9gatifs sur prophylaxie pr\u00e9exposition<\/strong> (PPrE ou PrEP).<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u00c0 partir de donn\u00e9es extraites de la Australian Collaboration for Coordinated Enhanced and Blood-borne Viruses \u2013 ACCESS<\/a><\/strong>, les chercheurs ont observ\u00e9 les changements dans l\u2019incidence de l\u2019h\u00e9patite C (\u00e0 savoir le nombre de nouvelles infections) parmi les HARSAH vivant avec le VIH et les individus s\u00e9ron\u00e9gatifs, et ce, entre 2009 et 2019 et plus particuli\u00e8rement parmi les HARSAH s\u00e9ron\u00e9gatifs qui utilisaient la PrEP entre 2016 et 2019. Le param\u00e8tre principal mesur\u00e9 dans cette \u00e9tude a donc \u00e9t\u00e9 le nombre de nouvelles infections \u00e0 l\u2019h\u00e9patite C, d\u00e9tect\u00e9es \u00e0 la suite d\u2019un test de d\u00e9pistage des anticorps anti-VHC ou d\u2019un test d\u2019ARN viral.<\/p>\n\n\n\n

Un total de 6744 hommes vivant avec le VIH <\/strong>ont \u00e9t\u00e9 inclus dans l\u2019analyse, comprenant 33 150 personnes-ann\u00e9es de suivi avec 290 nouvelles infections \u00e0 l\u2019h\u00e9patite C pour la p\u00e9riode d\u2019\u00e9tude<\/strong>. Cela a produit une incidence totale de 1,03 par 100 personnes-ann\u00e9es<\/strong>, avec la plus haute incidence enregistr\u00e9e en 2010 (2,12 pour 100 personnes-ann\u00e9es) et la plus basse enregistr\u00e9e en 2019 (0,22 pour 100 personnes-ann\u00e9es).<\/p>\n\n\n\n

\n

L\u2019incidence a baiss\u00e9 de mani\u00e8re continuelle avec les ann\u00e9es, \u00e0 savoir de 60% en 2017, 35% en 2018 et 78% en 2019, en comparaison avec l\u2019ann\u00e9e 2015 de r\u00e9f\u00e9rence, o\u00f9 les AAD sont devenus accessibles en Australie.<\/p>\n<\/blockquote>\n\n\n\n

Parmi les 20 590 HARSAH s\u00e9ron\u00e9gatifs, l\u2019incidence du VHC \u00e9tait de 0,20 pour 100 personnes-ann\u00e9es, sans diff\u00e9rence significative de not\u00e9e \u00e0 travers le temps. Parmi les 11 661 HARSAH s\u00e9ron\u00e9gatifs sur PrEP, l\u2019incidence du VHC a \u00e9t\u00e9 de 0,29 pour 100 personnes-ann\u00e9es. En comparaison avec l\u2019ann\u00e9e 2016, l\u2019incidence parmi les HARSAH sur PrEP a d\u00e9clin\u00e9 de 80% en 2019.<\/strong><\/p>\n\n\n\n

En conclusion, l\u2019incidence du VHC parmi les HARSAH vivant avec le VIH a chut\u00e9 \u00e0 la suite de la mise \u00e0 disposition des AAD<\/strong>, alors qu\u2019il n\u2019y avait pas de changement observ\u00e9 dans l\u2019incidence du VHC parmi l\u2019ensemble de tous les HARSAH s\u00e9ron\u00e9gatifs et que parmi les HARSAH sur PrEP, l\u2019incidence a d\u00e9clin\u00e9 depuis les premi\u00e8res ann\u00e9es d\u2019instauration de la PrEP en Australie.<\/p>\n\n\n\n

L\u2019Australie serait donc sur la voie de l\u2019\u00e9limination de l\u2019h\u00e9patite C parmi la population HARSAH, selon les auteurs, et ce, bien avant les objectifs de 2030 fix\u00e9s par l\u2019OMS.<\/p>\n\n\n\n

Traduit de l\u2019anglais, source PNMVH D\u00e9cembre 2021<\/p>\n\n\n\n

Post\u00e9 : 22 D\u00e9cembre 2021<\/p>","protected":false},"excerpt":{"rendered":"

L\u2019Australie en voie d\u2019\u00e9liminer le VHC chez les HARSAH d\u2019ici 2030 L\u2019h\u00e9patite C affecte de mani\u00e8re disproportionn\u00e9e les hommes ayant des relations sexuelles avec d\u2019autres hommes (HARSAH) vivant avec le VIH. Une infime partie de HARSAH s\u00e9ron\u00e9gatifs \u2013 plus particuli\u00e8rement ceux prenant la PrEP \u2013 peuvent aussi \u00eatre affect\u00e9s. Cependant, l\u2019introduction des antiviraux \u00e0 action […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2157","post","type-post","status-publish","format-standard","hentry","category-nouvelles-articles"],"blocksy_meta":[],"yoast_head":"\nL\u2019Australie en voie d\u2019\u00e9liminer le VHC chez les HARSAH d\u2019ici 2030 - CAPAHC<\/title>\n<meta name=\"description\" content=\"Dans une\u00a0\u00e9tude\u00a0men\u00e9e par le Dr Brendan Harney, B. L., & al. 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